Article
Essential roles for Fe65, Alzheimer amyloid precursor-binding protein, in the cellular response to DNA damage.
The Journal of biological chemistry - 12 Jan 2007
Minopoli Giuseppina, Stante Maria, Napolitano Francesco, Telese Francesca, Aloia Luigi, De Felice Mario, Di Lauro Roberto, Pacelli Roberto, Brunetti Arturo, Zambrano Nicola, Russo Tommaso
Abstract excerpt
Fe65 interacts with the cytosolic domain of the Alzheimer amyloid precursor protein (APP). The functions of the Fe65 are still unknown. To address this point we generated Fe65 knockout (KO) mice. These mice do not show any obvious phenotype; however, when fibroblasts (mouse embryonic fibroblasts), isolated from Fe65 KO embryos, were exposed to low doses of DNA damaging agents, such as etoposide or H2O2, an...
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