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Inhibition of Dectin-1 Ameliorates Neuroinflammation by Regulating Microglia/Macrophage Phenotype After Intracerebral Hemorrhage in Mice.

Translational stroke research - 1 Dec 2021

Fu Xiongjie, Zeng Hanhai, Zhao Jikuang, Zhou Guoyang, Zhou Hang, Zhuang Jianfeng, Xu Chaoran, Li Jianru, Peng Yucong, Cao Yang, Li Yin, Chen Huaijun, Wang Lin, Yan Feng, Chen Gao

Abstract excerpt

Polarization of microglia/macrophages toward the pro-inflammatory phenotype is an important contributor to neuroinflammation after intracerebral hemorrhage (ICH). Dectin-1 is a pattern recognition receptor that has been reported to play a key role in regulating neuroinflammation in ischemic stroke and spinal cord injury. However, the role and mechanism of action of Dectin-1 after ICH remains unclear. In this...

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PMID: 33539006
DOI: 10.1007/s12975-021-00889-2

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