Article
c-Myb Regulates Proliferation and Differentiation of Adventitial Sca1+ Vascular Smooth Muscle Cell Progenitors by Transactivation of Myocardin.
Arteriosclerosis, thrombosis, and vascular biology - 1 Jul 2016
Shikatani Eric A, Chandy Mark, Besla Rickvinder, Li Cedric C, Momen Abdul, El-Mounayri Omar, Robbins Clinton S, Husain Mansoor
Abstract excerpt
OBJECTIVE: Vascular smooth muscle cells (VSMCs) are believed to dedifferentiate and proliferate in response to vessel injury. Recently, adventitial progenitor cells were implicated as a source of VSMCs involved in vessel remodeling. c-Myb is a transcription factor known to regulate VSMC proliferation in vivo and differentiation of VSMCs from mouse embryonic stem cell-derived progenitors in vitro. However, the...
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