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Article

Myocardin regulates expression of contractile genes in smooth muscle cells and is required for closure of the ductus arteriosus in mice.

The Journal of clinical investigation - 1 Feb 2008

Huang Jianhe, Cheng Lan, Li Jian, Chen Mary, Zhou Deying, Lu Min Min, Proweller Aaron, Epstein Jonathan A, Parmacek Michael S

Abstract excerpt

Myocardin (Myocd) is a potent transcriptional coactivator that has been implicated in cardiovascular development and adaptation of the cardiovascular system to hemodynamic stress. To determine the function of myocardin in the developing cardiovascular system, Myocd(F/F)/Wnt1-Cre(+) and Myocd(F/F)/Pax3-Cre(+) mice were generated in which the myocardin gene was selectively ablated in neural crest-derived SMCs...

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Share to Ductus Arteriosus, Patent
Share to Gene Expression Regulation, Developmental

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Muscle Contraction

Share to Myocytes, Smooth Muscle

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Share to Nuclear Proteins

Share to Sequence Deletion

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Source

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Identifiers

PMID: 18188448
DOI: 10.1172/JCI33304
PMCID: PMC2176191

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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