Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Stem cells and their derivatives can bypass the requirement of myocardin for smooth muscle gene expression.

Developmental biology - 15 Dec 2005

Pipes G C Teg, Sinha Sanjay, Qi Xiaoxia, Zhu Chun-Hong, Gallardo Teresa D, Shelton John, Creemers Esther E, Sutherland Lillian, Richardson James A, Garry Daniel J, Wright Woodring E, Owens Gary K, Olson Eric N

Abstract excerpt

The Serum Response Factor (SRF) coactivator myocardin stimulates the transcription of multiple muscle genes during cardiac and smooth muscle development. Mouse embryos lacking myocardin die during the earliest stages of smooth muscle development and fail to express multiple smooth muscle marker genes in the embryonic dorsal aorta and other vascular structures. In this study, we used mutant embryonic stem cell...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Lineage
Share to Embryo, Mammalian

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mice, Mutant Strains

Share to Muscle, Skeletal

Share to Muscle, Smooth

Share to Myocardium

Share to Stem Cells

Share to Trans-Activators

Source

Identifiers

PMID: 16310178
DOI: 10.1016/j.ydbio.2005.10.014

Genes

SRF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Stem cells and their derivatives can bypass the requirement of myocardin for smooth muscle gene expression.PMID 16310178Read ↗

The serum response factor coactivator myocardin is required for vascular smooth muscle development.Semantic proximity Read ↗

Myocardin is a master regulator of smooth muscle gene expression.Semantic proximity Read ↗

Myocardin is differentially required for the development of smooth muscle cells and cardiomyocytesSemantic proximity Read ↗

Myocardin overexpression is sufficient for promoting the development of a mature smooth muscle cell-like phenotype from human embryonic stem cells.Semantic proximity Read ↗

Myocardin is sufficient and necessary for cardiac gene expression in Xenopus.Semantic proximity Read ↗

Myocardin regulates expression of contractile genes in smooth muscle cells and is required for closure of the ductus arteriosus in mice.Semantic proximity Read ↗

Myocardin and ternary complex factors compete for SRF to control smooth muscle gene expression.Semantic proximity Read ↗

Myocardin-related transcription factor B is required for normal mouse vascular development and smooth muscle gene expression.Semantic proximity Read ↗

Myocardin is required for maintenance of vascular and visceral smooth muscle homeostasis during postnatal development.Semantic proximity Read ↗

The mechanism of stem cell differentiation into smooth muscle cellsSemantic proximity Read ↗

Requirement of myocardin-related transcription factor-B for remodeling of branchial arch arteries and smooth muscle differentiation.Semantic proximity Read ↗

Molecular regulation of vascular smooth muscle cell differentiation in development and disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.