Article
Early reduced liver graft survival in hepatitis C recipients identified by two combined genetic markers.
Transplant international : official journal of the European Society for Organ Transplantation - 1 Oct 2016
Romagnoli Renato, Martini Silvia, Tandoi Francesco, Dell Olio Dominic, Magistroni Paola, Bertinetto Francesca E, Dametto Ennia, Rizzetto Mario, Salizzoni Mauro, Amoroso Antonio
Abstract excerpt
HLA and IL-28B genes were independently associated with severity of HCV-related liver disease. We investigated the effects of these combined genetic factors on post-transplant survival in HCV-infected recipients, aiming to provide new data to define the optimal timing of novel antiviral therapies in the transplant setting. HLA-A/B/DRB1 alleles and IL-28B rs12979860 (C > T) polymorphism frequencies were determined...
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