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Hepatitis C virus-specific T-cell response correlates with hepatitis activity and donor IL28B genotype early after liver transplantation.

Acta medica Okayama - 1 Jan 2014

Tsuzaki Ryuichiro, Takaki Akinobu, Yagi Takahito, Ikeda Fusao, Koike Kazuko, Iwasaki Yoshiaki, Shiraha Hidenori, Miyake Yasuhiro, Sadamori Hiroshi, Shinoura Susumu, Umeda Yuzo, Yoshida Ryuichi, Nobuoka Daisuke, Utsumi Masashi, Nakayama Eiichi, Fujiwara Toshiyoshi, Yamamoto Kazuhide

Abstract excerpt

It is not known how the immune system targets hepatitis C virus (HCV)-infected HLA-mismatched hepatocytes under immune-suppressed conditions after orthotopic liver transplantation (OLT). In addition, the relationship between the HCV-specific immune response and IL28B variants as predictors of HCV clearance has not been well-characterized. We determined the IL28B polymorphisms for 57 post-OLT HCV carriers, and we...

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PMID: 25338486
DOI: 10.18926/AMO/52898

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