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Article

Importance of host genetic factors HLA and IL28B as predictors of response to pegylated interferon and ribavirin.

The American journal of gastroenterology - 1 Jul 2011

de Rueda Paloma Muñoz, López-Nevot Miguel-Ángel, Sáenz-López Pablo, Casado Jorge, Martín-Casares Antonia, Palomares Pablo, Quiles Rosa, Gila Ana, Romero-Gómez Manuel, Pavón Esther-José, Muñoz José-Antonio, Carazo Angel, Sanz-Cameno Paloma, Moreno-Otero Ricardo, Diago Moisés, León Josefa, Ruiz-Extremera Angeles, Salmerón Javier

Abstract excerpt

OBJECTIVES: Viral factors are considered the best predictors of response to treatment for chronic hepatitis C (CHC), but genetic factors are known to have an important role in this respect. This paper investigates the relationships among the host genetic factors HLA and IL28B, viral factors, and the outcome of combination therapy. METHODS: A multicenter retrospective cohort of 428 previously untreated CHC...

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PMID: 21670772
DOI: 10.1038/ajg.2011.82

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