Role of IL28B polymorphism in the development of hepatitis C virus-induced hepatocellular carcinoma, graft fibrosis, and posttransplant antiviral therapy.

doi:10.1097/TP.0b013e318244f774

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Role of IL28B polymorphism in the development of hepatitis C virus-induced hepatocellular carcinoma, graft fibrosis, and posttransplant antiviral therapy.

Transplantation - 27 Mar 2012

Eurich Dennis, Boas-Knoop Sabine, Bahra Marcus, Neuhaus Ruth, Somasundaram Rajan, Neuhaus Peter, Neumann Ulf, Seehofer Daniel

Abstract excerpt

BACKGROUND: The development of liver graft disease is partially determined by individual genetic background. Interleukin 28B (IL28B) is strongly suspected to be involved in susceptibility for hepatitis C virus (HCV) infection, inflammation, and antiviral treatment response before and after liver transplantation (LT). Currently, the role of IL28B polymorphism (rs12979860) in the development of hepatocellular...

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PMID: 22411462
DOI: 10.1097/TP.0b013e318244f774

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