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Article

MFG-E8 mediates primary phagocytosis of viable neurons during neuroinflammation.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 22 Feb 2012

Fricker Michael, Neher Jonas J, Zhao Jing-Wei, Théry Clotilde, Tolkovsky Aviva M, Brown Guy C

Abstract excerpt

Milk-fat globule EGF factor-8 (MFG-E8, SED1, lactadherin) is known to mediate the phagocytic removal of apoptotic cells by bridging phosphatidylserine (PS)-exposing cells and the vitronectin receptor (VR) on phagocytes. However, we show here that MFG-E8 can mediate phagocytosis of viable neurons during neuroinflammation induced by lipopolysaccharide (LPS), thereby causing neuronal death. In vitro, inflammatory...

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Identifiers

PMID: 22357850
DOI: 10.1523/JNEUROSCI.4837-11.2012
PMCID: PMC3312099

Genes

EGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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