Article
Phenotyping of difficult asthma using longitudinal physiological and biomarker measurements reveals significant differences in stability between clusters.
BMC pulmonary medicine - 10 May 2016
Zaihra T, Walsh C J, Ahmed S, Fugère C, Hamid Q A, Olivenstein R, Martin J G, Benedetti A
Abstract excerpt
BACKGROUND: Although the heterogeneous nature of asthma has prompted asthma phenotyping with physiological or biomarker data, these studies have been mostly cross-sectional. Longitudinal studies that assess the stability of phenotypes based on a combination of physiological, clinical and biomarker data are currently lacking. Our objective was to assess the longitudinal stability of clusters derived from repeated...
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