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Article

Sputum microbiome profiles identify severe asthma phenotypes of relative stability at 12 to 18 months

27 Apr 2020

Abstract excerpt

BACKGROUND: Asthma is a heterogeneous disease characterized by distinct phenotypes with associated microbial dysbiosis. OBJECTIVES: Our aim was to identify severe asthma phenotypes based on sputum microbiome profiles and assess their stability after 12 to 18 months. A further aim was to evaluate clusters' robustness after inclusion of an independent cohort of patients with mild-to-moderate asthma. METHODS: In...

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PMID: 32353491
DOI: 10.1016/j.jaci.2020.04.018

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