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Article

Functional phenotypes determined by fluctuation-based clustering of lung function measurements in healthy and asthmatic cohort participants.

Thorax - 1 Feb 2018

Delgado-Eckert Edgar, Fuchs Oliver, Kumar Nitin, Pekkanen Juha, Dalphin Jean-Charles, Riedler Josef, Lauener Roger, Kabesch Michael, Kupczyk Maciej, Dahlen Sven-Erik, Mutius Erika von, Frey Urs

Abstract excerpt

RATIONALE: Asthma is characterised by inflammation and reversible airway obstruction. However, these features are not always closely related. Fluctuations of daily lung function contain information on asthma phenotypes, exacerbation risk and response to long-acting β-agonists. OBJECTIVES: In search of subgroups of asthmatic participants with specific lung functional features, we developed and validated a novel...

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PMID: 28866644
DOI: 10.1136/thoraxjnl-2016-209919

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