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Article

Alzheimer disease-related presenilin-1 variants exert distinct effects on monoamine oxidase-A activity in vitro.

Journal of neural transmission (Vienna, Austria : 1996) - 1 Jul 2011

Pennington Paul R, Wei Zelan, Rui Lewei, Doig Jennifer A, Graham Brett, Kuski Kelly, Gabriel Geraldine G, Mousseau Darrell D

Abstract excerpt

Monoamine oxidase-A (MAO-A) has been associated with both depression and Alzheimer disease (AD). Recently, carriers of AD-related presenilin-1 (PS-1) alleles have been found to be at higher risk for developing clinical depression. We chose to examine whether PS-1 could influence MAO-A function in vitro. Overexpression of selected AD-related PS-1 variants (wildtype, Y115H, ΔEx9 and M146V) in mouse hippocampal...

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Identifiers

PMID: 21373759
DOI: 10.1007/s00702-011-0616-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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