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Article

5-HT1B and other related serotonergic proteins are altered in APPswe mutation.

Neuroscience letters - 6 May 2015

Tajeddinn Walid, Persson Torbjörn, Maioli Silvia, Calvo-Garrido Javier, Parrado-Fernandez Cristina, Yoshitake Takashi, Kehr Jan, Francis Paul, Winblad Bengt, Höglund Kina, Cedazo-Minguez Angel, Aarsland Dag

Abstract excerpt

Serotonergic dysfunction is implicated in Alzheimer's disease (AD). In addition, reductions in brain of both monoamine synthesis and release have been reported. Serotonin 1B receptors (5-HT1B), along with serotonin transporter (SERT) are among the regulators of extracellular 5-HT levels. We investigated the effect of the familial AD APP (Amyloid precursor protein) K670N/M671L double mutation, APP Swedish mutation...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 25841787
DOI: 10.1016/j.neulet.2015.03.064

Genes

MAOA
APP

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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