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Article

Modulation of serotonergic receptor signaling and cross-talk by prion protein.

The Journal of biological chemistry - 11 Feb 2005

Mouillet-Richard Sophie, Pietri Mathéa, Schneider Benoît, Vidal Catherine, Mutel Vincent, Launay Jean-Marie, Kellermann Odile

Abstract excerpt

The inducible serotonergic 1C115-HT cell line expresses a defined set of serotonergic receptors of the 5-HT2B, 5-HT1B/D, and 5-HT2A subtypes, which sustain a regulation of serotonergic associated functions through G-protein-dependent signaling. 1C115-HT cells have been instrumental to assign a signaling function to the cellular prion protein PrPC. Here, we establish that antibody-mediated ligation of PrPC...

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PMID: 15590675
DOI: 10.1074/jbc.M406199200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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