Article
Serotonin transporters are preserved in the neocortex of anxious Alzheimer's disease patients.
Neuroreport - 18 Jul 2003
Tsang Shirley W Y, Lai Mitchell K P, Francis Paul T, Wong Peter T-H, Spence Ian, Esiri Margaret M, Keene Janet, Hope Tony, Chen Christopher P L-H
Abstract excerpt
Densities of serotonin transporters (5-HTT) in the postmortem neocortex of behaviorally assessed Alzheimer's disease (AD) patients and aged controls were measured by radioligand binding with [3H]citalopram. It was found that 5-HTT sites in the temporal cortex of AD patients with prominent antemortem anxiety were unaltered compared with controls, but were reduced in non-anxious AD subjects. Furthermore,...
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