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Article

No significant effect of 7,8-dihydroxyflavone on APP processing and Alzheimer-associated phenotypes.

Current Alzheimer research - 1 Jan 2015

Zhou Weitao, Li Xiaoyong, Huang Daochao, Zhou Weihui, Li Tingyu, Song Weihong

Abstract excerpt

It is reported that 7,8-dihydroxyflavone (DHF), a TrkB agonist, has beneficial effects on neuronal excitotoxicity, stroke, and Parkinson disease in animal models by enhancing axon regeneration, muscle reinnervation and neuromuscular transmission. The effect of DHF on AD neuropathology remains not well defined. In this study we examined whether DHF affects APP processing and cognitive functions in vitro and in...

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Source

Identifiers

PMID: 25523427
DOI: 10.2174/1567205012666141218124243

Genes

APP
BACE1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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