Differences in the Selection Bottleneck between Modes of Sexual Transmission Influence the Genetic Composition of the HIV-1 Founder Virus.

doi:10.1371/journal.ppat.1005619

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Article

Differences in the Selection Bottleneck between Modes of Sexual Transmission Influence the Genetic Composition of the HIV-1 Founder Virus.

PLoS pathogens - 1 May 2016

Tully Damien C, Ogilvie Colin B, Batorsky Rebecca E, Bean David J, Power Karen A, Ghebremichael Musie, Bedard Hunter E, Gladden Adrianne D, Seese Aaron M, Amero Molly A, Lane Kimberly, McGrath Graham, Bazner Suzane B, Tinsley Jake, Lennon Niall J, Henn Matthew R, Brumme Zabrina L, Norris Philip J, Rosenberg Eric S, Mayer Kenneth H, Jessen Heiko, Kosakovsky Pond Sergei L, Walker Bruce D, Altfeld Marcus, Carlson Jonathan M, Allen Todd M

Abstract excerpt

Due to the stringent population bottleneck that occurs during sexual HIV-1 transmission, systemic infection is typically established by a limited number of founder viruses. Elucidation of the precise forces influencing the selection of founder viruses may reveal key vulnerabilities that could aid in the development of a vaccine or other clinical interventions. Here, we utilize deep sequencing data and apply a...

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PMID: 27163788
DOI: 10.1371/journal.ppat.1005619
PMCID: PMC4862634

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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