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Functional distance between recipient and donor HLA-DPB1 determines nonpermissive mismatches in unrelated HCT

9 May 2016

Abstract excerpt

The role of HLA amino acid (AA) polymorphism for the outcome of hematopoietic cell transplantation (HCT) is controversial, in particular for HLA class II. Here, we investigated this question in nonpermissive HLA-DPB1 T-cell epitope (TCE) mismatches reflected by numerical functional distance (FD) scores, assignable to all HLA-DPB1 alleles based on the combined impact of 12 polymorphic AAs. We calculated the...

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PMID: 27162243
DOI: 10.1182/blood-2015-12-686238

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