The Human Leukocyte Antigen-DPB1 Degree of Compatibility Is Determined by Its Expression Level and Mismatch Permissiveness: A German Multicenter Analysis.

doi:10.3389/fimmu.2020.614976

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Article

The Human Leukocyte Antigen-DPB1 Degree of Compatibility Is Determined by Its Expression Level and Mismatch Permissiveness: A German Multicenter Analysis.

Frontiers in immunology - 1 Jan 2020

Mytilineos Daphne, Tsamadou Chrysanthi, Neuchel Christine, Platzbecker Uwe, Bunjes Donald, Schub Natalie, Wagner-Drouet Eva, Wulf Gerald, Kröger Nicolaus, Murawski Niels, Einsele Hermann, Schaefer-Eckart Kerstin, Freitag Sebastian, Casper Jochen, Kaufmann Martin, Dürholt Mareike, Hertenstein Bernd, Klein Stefan, Ringhoffer Mark, Mueller Carlheinz R, Frank Sandra, Schrezenmeier Hubert, Fuerst Daniel, Mytilineos Joannis

Abstract excerpt

T-cell epitope matching according to the TCE3 algorithm classifies HLA-DPB1 mismatches in permissive and non-permissive. This classification has been shown to be predictive for mortality and acute GvHD (aGvHD) events in large international cohorts. We retrospectively genotyped HLA-DPB1 in 3523 patients transplanted in Germany between 2000 and 2014 and in their unrelated donors using an Illumina amplicon-NGS based...

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Identifiers

PMID: 33569061
DOI: 10.3389/fimmu.2020.614976
PMCID: PMC7868530

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Source receipt: pubmed, retrieved 7 Sept 2026.

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