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Article

Tumour resistance in induced pluripotent stem cells derived from naked mole-rats.

Nature communications - 10 May 2016

Miyawaki Shingo, Kawamura Yoshimi, Oiwa Yuki, Shimizu Atsushi, Hachiya Tsuyoshi, Bono Hidemasa, Koya Ikuko, Okada Yohei, Kimura Tokuhiro, Tsuchiya Yoshihiro, Suzuki Sadafumi, Onishi Nobuyuki, Kuzumaki Naoko, Matsuzaki Yumi, Narita Minoru, Ikeda Eiji, Okanoya Kazuo, Seino Ken-Ichiro, Saya Hideyuki, Okano Hideyuki, Miura Kyoko

Abstract excerpt

The naked mole-rat (NMR, Heterocephalus glaber), which is the longest-lived rodent species, exhibits extraordinary resistance to cancer. Here we report that NMR somatic cells exhibit a unique tumour-suppressor response to reprogramming induction. In this study, we generate NMR-induced pluripotent stem cells (NMR-iPSCs) and find that NMR-iPSCs do not exhibit teratoma-forming tumorigenicity due to the...

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PMID: 27161380
DOI: 10.1038/ncomms11471
PMCID: PMC4866046

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ERAS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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