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Article

Mutant p53 facilitates somatic cell reprogramming and augments the malignant potential of reprogrammed cells.

The Journal of experimental medicine - 27 Sept 2010

Sarig Rachel, Rivlin Noa, Brosh Ran, Bornstein Chamutal, Kamer Iris, Ezra Osnat, Molchadsky Alina, Goldfinger Naomi, Brenner Ori, Rotter Varda

Abstract excerpt

p53 deficiency enhances the efficiency of somatic cell reprogramming to a pluripotent state. As p53 is usually mutated in human tumors and many mutated forms of p53 gain novel activities, we studied the influence of mutant p53 (mut-p53) on somatic cell reprogramming. Our data indicate a novel gain of function (GOF) property for mut-p53, which markedly enhanced the efficiency of the reprogramming process compared...

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Identifiers

PMID: 20696700
DOI: 10.1084/jem.20100797
PMCID: PMC2947075

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Source receipt: pubmed, retrieved 7 Sept 2026.

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