Article
Mitochondrial DNA variants as genetic risk factors for Parkinson disease.
European journal of neurology - 1 Aug 2016
Liou C W, Chuang J H, Chen J B, Tiao M M, Wang P W, Huang S T, Huang T L, Lee W C, Weng S W, Huang P H, Chen S D, Chen R S, Lu C S, Lin T K
Abstract excerpt
BACKGROUND AND PURPOSE: Investigation of the relationship between mitochondrial DNA (mtDNA) variants and Parkinson disease (PD) remains an issue awaiting more supportive evidence. Moreover, an affirming cellular model study is also lacking. METHODS: The index mtDNA variants and their defining mitochondrial haplogroup were determined in 725 PD patients and 744 non-PD controls. Full-length mtDNA sequences were also...
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