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Mitochondrial DNA haplogroups and subhaplogroups are associated with Parkinson's disease risk in a Polish PD cohort.

Journal of neural transmission (Vienna, Austria : 1996) - 1 Nov 2008

Gaweda-Walerych Katarzyna, Maruszak Aleksandra, Safranow Krzysztof, Bialecka Monika, Klodowska-Duda Gabriela, Czyzewski Krzysztof, Slawek Jaroslaw, Rudzinska Monika, Styczynska Maria, Opala Grzegorz, Drozdzik Marek, Canter Jeffrey A, Barcikowska Maria, Zekanowski Cezary

Abstract excerpt

mtDNA common variation is inconsistently reported to modify the risk of Parkinson's disease (PD). We evaluated the impact of the mitochondrial haplogroups, subhaplogroups, coding and non-coding single-nucleotide polymorphisms on PD risk in 241 PD patients and 277 control subjects. After stratification by gender, we found that haplogroup J (OR 0.19; 95% CI 0.069-0.53; P = 0.0014) was associated with a lower PD...

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PMID: 18810306
DOI: 10.1007/s00702-008-0121-9

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