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Mitochondrial DNA variants, haplogroups and risk of Parkinson's disease: A systematic review and meta-analysis.

Parkinsonism & related disorders - 1 Aug 2024

Sena-Dos-Santos Camille, Moura Dafne Dalledone, Epifane-de-Assunção Matheus Caetano, Ribeiro-Dos-Santos Ândrea, Santos-Lobato Bruno Lopes

Abstract excerpt

BACKGROUND: Growing evidence has shown that mitochondrial dysfunction is part of the pathogenesis of Parkinson's disease (PD). However, the role of mitochondrial DNA (mtDNA) variants on PD onset is unclear. OBJECTIVES: The present study aims to evaluate the effect of mtDNA variants and haplogroups on risk of developing PD. METHODS: Systematic review and meta-analysis of studies investigating associations between...

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PMID: 38917640
DOI: 10.1016/j.parkreldis.2024.107044

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