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Article

A missense MT-ND5 mutation in differentiated Parkinson Disease cytoplasmic hybrid induces ROS-dependent DNA Damage Response amplified by DROSHA.

Scientific reports - 25 Aug 2017

Pignataro Daniela, Francia Sofia, Zanetta Francesca, Brenna Giulia, Brandini Stefania, Olivieri Anna, Torroni Antonio, Biamonti Giuseppe, Montecucco Alessandra

Abstract excerpt

Genome integrity is continuously threatened by endogenous sources of DNA damage including reactive oxygen species (ROS) produced by cell metabolism. Factors of the RNA interference (RNAi) machinery have been recently involved in the cellular response to DNA damage (DDR) in proliferating cells. To investigate the impact of component of RNAi machinery on DDR activation in terminally differentiated cells, we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28842646
DOI: 10.1038/s41598-017-09910-x
PMCID: PMC5573376

Genes

DROSHA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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