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Article

Two-stage association study and meta-analysis of mitochondrial DNA variants in Parkinson disease.

Neurology - 28 May 2013

Hudson Gavin, Nalls Mike, Evans Jonathan R, Breen David P, Winder-Rhodes Sophie, Morrison Karen E, Morris Huw R, Williams-Gray Caroline H, Barker Roger A, Singleton Andrew B, Hardy John, Wood Nicholas E, Burn David J, Chinnery Patrick F

Abstract excerpt

OBJECTIVES: Previous associations between mitochondrial DNA (mtDNA) and idiopathic Parkinson disease (PD) have been inconsistent and contradictory. Our aim was to resolve these inconsistencies and determine whether mtDNA has a significant role in the risk of developing PD. METHODS: Two-stage genetic association study of 138 common mtDNA variants in 3,074 PD cases and 5,659 ethnically matched controls followed by...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23645593
DOI: 10.1212/WNL.0b013e318294b434
PMCID: PMC3716399

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