Exome-wide Association Study Identifies CLEC3B Missense Variant p.S106G as Being Associated With Extreme Longevity in East Asian Populations.

doi:10.1093/gerona/glw074

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Article

Exome-wide Association Study Identifies CLEC3B Missense Variant p.S106G as Being Associated With Extreme Longevity in East Asian Populations.

The journals of gerontology. Series A, Biological sciences and medical sciences - 1 Mar 2017

Tanisawa Kumpei, Arai Yasumichi, Hirose Nobuyoshi, Shimokata Hiroshi, Yamada Yoshiji, Kawai Hisashi, Kojima Motonaga, Obuchi Shuichi, Hirano Hirohiko, Yoshida Hideyo, Suzuki Hiroyuki, Fujiwara Yoshinori, Ihara Kazushige, Sugaya Maki, Arai Tomio, Mori Seijiro, Sawabe Motoji, Sato Noriko, Muramatsu Masaaki, Higuchi Mitsuru, Liu Yao-Wen, Kong Qing-Peng, Tanaka Masashi

Abstract excerpt

Life span is a complex trait regulated by multiple genetic and environmental factors; however, the genetic determinants of extreme longevity have been largely unknown. To identify the functional coding variants associated with extreme longevity, we performed an exome-wide association study (EWAS) on a Japanese population by using an Illumina HumanExome Beadchip and a focused replication study on a Chinese...

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PMID: 27154906
DOI: 10.1093/gerona/glw074
PMCID: PMC5861862

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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