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Article

The role of polymorphisms of stromal-derived factor-1 and CXC receptor 4 in acute myeloid leukemia and leukemia cell dissemination.

Gene - 22 Aug 2016

Zheng Qin, Shuai Xiao, Ye Yuanxin, Jin Yongmei, Jiang Nenggang, Chen Xingyuan, Su Jun

Abstract excerpt

BACKGROUND: Acute myeloid leukemia (AML) is a form of cancer characterized by infiltration of the bone marrow, blood, and other tissues by proliferative, clonal, abnormally differentiated cells of the hematopoietic system. Chemokine stromal cell-derived factor 1 (SDF-1) and its receptor CXC receptor 4 (CXCR4) play crucial roles in malignant cell invasion. Genetic polymorphisms may contribute to the differences in...

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Share to Chemokine CXCL12
Share to Gene Expression Regulation, Leukemic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genotyping Techniques

Share to Leukemia, Myeloid, Acute

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Share to Leukocytes, Mononuclear

Share to Neoplastic Cells, Circulating

Share to Receptors, CXCR4

Source

Identifiers

PMID: 27154815
DOI: 10.1016/j.gene.2016.04.059

Genes

CXCR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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