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Article

Stromal cell derived factor-1 (CXCL12) chemokine gene variant in myeloid leukemias.

Clinical laboratory - 1 Jan 2014

El-Ghany Hoda Mohamed A, El-Saadany Zainab Ali, Bahaa Nevien Mohamed, Ibrahim Noha Yehia, Hussien Salwa Mahmoud

Abstract excerpt

BACKGROUND: Acute and chronic myeloid leukemia are initiated and sustained by a small, self-renewing population of leukemic stem cells, which produce progeny of a heterogeneous population of progenitor cells. CXCL12, a chemokine abundantly produced by the bone marrow microenvironment, and its receptor CXCR4 have crucial roles in malignant cell trafficking. We set out to determine the CXCL12 gene polymorphism at...

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Source

Identifiers

PMID: 24839815
DOI: 10.7754/clin.lab.2013.130445

Genes

CXCL12
CXCR4

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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