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CXCR4 downregulation of let-7a drives chemoresistance in acute myeloid leukemia

7 May 2013

Abstract excerpt

We examined the role of microRNAs (miRNAs) in targeting the stromal-derived factor 1α/CXCR4 (SDF-1α/CXCR4) axis to overcome chemoresistance of AML cells. Microarray analysis of OCI-AML3 cells revealed that the miRNA let-7a was downregulated by SDF-1α-mediated CXCR4 activation and increased by CXCR4 inhibition. Overexpression of let-7a in AML cell lines was associated with decreased c-Myc and BCL-XL protein...

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PMID: 23676502
DOI: 10.1172/jci66553

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