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Functional polymorphisms in the CD44 gene and acute myeloid leukemia cancer risk in a Chinese population.

Molecular carcinogenesis - 1 Feb 2015

Wu Hongchun, Deng Jieqiong, Zheng Jian, You Yonghe, Li Na, Li Wei, Wu Depei, Zhou Yifeng

Abstract excerpt

CD44 is such one adhesion molecule that mediates interactions between acute myeloid leukemia (AML) cells and stromal. It has been demonstrated that CD4 plays a critical role in AML development. However, studies of functional single nucleotide polymorphisms (SNPs) in CD44 gene have not touched upon AML. This case-control study probed the contribution of functional SNPs in CD44 gene to AML susceptibility in eastern...

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PMID: 24038513
DOI: 10.1002/mc.22078

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