Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Obligatory and facilitative allelic variation in the DNA methylome within common disease-associated loci.

Nature communications - 2 Jan 2018

Bell Christopher G, Gao Fei, Yuan Wei, Roos Leonie, Acton Richard J, Xia Yudong, Bell Jordana, Ward Kirsten, Mangino Massimo, Hysi Pirro G, Wang Jun, Spector Timothy D

Abstract excerpt

Integrating epigenetic data with genome-wide association study (GWAS) results can reveal disease mechanisms. The genome sequence itself also shapes the epigenome, with CpG density and transcription factor binding sites (TFBSs) strongly encoding the DNA methylome. Therefore, genetic polymorphism impacts on the observed epigenome. Furthermore, large genetic variants alter epigenetic signal dosage. Here, we identify...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CpG Islands
Share to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Methylation

Share to Epigenesis, Genetic

Share to Genome, Human

Share to Genome-Wide Association Study

Share to Haplotypes

Share to High-Throughput Nucleotide Sequencing

Source

Open in PubMed Open full text

Identifiers

PMID: 29295990
DOI: 10.1038/s41467-017-01586-1
PMCID: PMC5750212

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Obligatory and facilitative allelic variation in the DNA methylome within common disease-associated loci.PMID 29295990Read ↗

Functional variation in allelic methylomes underscores a strong genetic contribution and reveals novel epigenetic alterations in the human epigenome.Semantic proximity Read ↗

Human panepigenome represents epigenomic diversitySemantic proximity Read ↗

An atlas of genetic effects on the monocyte methylome across European and African populationsSemantic proximity Read ↗

Genetic variation influencing DNA methylation provides insights into molecular mechanisms regulating genomic function.Semantic proximity Read ↗

Genomic and phenomic insights from an atlas of genetic effects on DNA methylationSemantic proximity Read ↗

Genomic and phenotypic insights from an atlas of genetic effects on DNA methylation.Semantic proximity Read ↗

Exploring the Genetic Basis of Human Population Differences in DNA Methylation and their Causal Impact on Immune Gene RegulationSemantic proximity Read ↗

Genetic-epigenetic interactions in cis: a major focus in the post-GWAS era.Semantic proximity Read ↗

Allele-specific DNA methylation is increased in cancers and its dense mapping in normal plus neoplastic cells increases the yield of disease-associated regulatory SNPs.Semantic proximity Read ↗

Mechanisms and Disease Associations of Haplotype-Dependent Allele-Specific DNA Methylation.Semantic proximity Read ↗

Genetic impacts on DNA methylation help elucidate regulatory genomic processesSemantic proximity Read ↗

Allele-specific methylation occurs at genetic variants associated with complex disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.