Article
Activation of Endogenous Retroviruses in Dnmt1(-/-) ESCs Involves Disruption of SETDB1-Mediated Repression by NP95 Binding to Hemimethylated DNA.
Cell stem cell - 7 Jul 2016
Sharif Jafar, Endo Takaho A, Nakayama Manabu, Karimi Mohammad M, Shimada Midori, Katsuyama Kayoko, Goyal Preeti, Brind'Amour Julie, Sun Ming-An, Sun Zhixiong, Ishikura Tomoyuki, Mizutani-Koseki Yoko, Ohara Osamu, Shinkai Yoichi, Nakanishi Makoto, Xie Hehuang, Lorincz Matthew C, Koseki Haruhiko
Abstract excerpt
Repression of endogenous retroviruses (ERVs) in mammals involves several epigenetic mechanisms. Acute loss of the maintenance methyltransferase Dnmt1 induces widespread DNA demethylation and transcriptional activation of ERVs, including CpG-rich IAP (intracisternal A particle) proviruses. Here, we show that this effect is not due simply to a loss of DNA methylation. Conditional deletions reveal that both Dnmt1...
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