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Article

Efficient RNA virus control in Drosophila requires the RNA methyltransferase Dnmt2.

EMBO reports - 1 Mar 2013

Durdevic Zeljko, Hanna Katharina, Gold Beth, Pollex Tim, Cherry Sara, Lyko Frank, Schaefer Matthias

Abstract excerpt

Drosophila use small-interfering RNA mechanisms to limit the amplification of viral genomes. However, it is unclear how small RNA interference components recognize and separate viral from cellular RNA. Dnmt2 enzymes are highly conserved RNA methyltransferases with substrate specificity towards cellular tRNAs. We report here that Dnmt2 is required for efficient innate immune responses in Drosophila. Dnmt2 mutant...

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Identifiers

PMID: 23370384
DOI: 10.1038/embor.2013.3
PMCID: PMC3589093

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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