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Article

Simultaneous profiling of transcriptome and DNA methylome from a single cell.

Genome biology - 5 May 2016

Hu Youjin, Huang Kevin, An Qin, Du Guizhen, Hu Ganlu, Xue Jinfeng, Zhu Xianmin, Wang Cun-Yu, Xue Zhigang, Fan Guoping

Abstract excerpt

BACKGROUND: Single-cell transcriptome and single-cell methylome technologies have become powerful tools to study RNA and DNA methylation profiles of single cells at a genome-wide scale. A major challenge has been to understand the direct correlation of DNA methylation and gene expression within single-cells. Due to large cell-to-cell variability and the lack of direct measurements of transcriptome and methylome...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27150361
DOI: 10.1186/s13059-016-0950-z
PMCID: PMC4858893

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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