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Article

Deep sequencing reveals cell-type-specific patterns of single-cell transcriptome variation.

Genome biology - 9 Jun 2015

Dueck Hannah, Khaladkar Mugdha, Kim Tae Kyung, Spaethling Jennifer M, Francis Chantal, Suresh Sangita, Fisher Stephen A, Seale Patrick, Beck Sheryl G, Bartfai Tamas, Kuhn Bernhard, Eberwine James, Kim Junhyong

Abstract excerpt

BACKGROUND: Differentiation of metazoan cells requires execution of different gene expression programs but recent single-cell transcriptome profiling has revealed considerable variation within cells of seeming identical phenotype. This brings into question the relationship between transcriptome states and cell phenotypes. Additionally, single-cell transcriptomics presents unique analysis challenges that need to...

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Identifiers

PMID: 26056000
DOI: 10.1186/s13059-015-0683-4
PMCID: PMC4480509

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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