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Article

The COMT rs4680 SNP participates in the regulation of the arousal threshold in patients with obstructive sleep apnea.

Sleep & breathing = Schlaf & Atmung - 14 Aug 2026

Martynowicz Helena, Jodkowska Anna, Fułek Michał, Smardz Joanna, Bort Marta, Gać Paweł, Przegrałek Jakub, Dratwa-Kuzmin Marta, Bogunia-Kubik Katarzyna, Więckiewicz Mieszko

Abstract excerpt

PURPOSE: To investigate whether the functional catechol-O-methyltransferase (COMT) rs4680 polymorphism is related to a predicted low respiratory arousal threshold (LAT) phenotype in adults with polysomnography-confirmed obstructive sleep apnea (OSA), and to assess selected dopaminergic pathway-related polymorphisms. METHODS: In this prospective observational study, 144 adults with OSA underwent polysomnography....

Topics

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Arousal
Catechol O-Methyltransferase
Genotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

Polysomnography

Receptors, Dopamine D1

Receptors, Dopamine D2

Sleep Apnea, Obstructive

Source

Open in PubMed Open full text

Identifiers

PMID: 42599341
DOI: 10.1007/s11325-026-03775-z
PMCID: PMC13476348

Genes

LAT
COMT
DRD1
DRD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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