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Article

Presenilin 1 promotes trypsin-induced neuroprotection via the PAR2/ERK signaling pathway. Effects of presenilin 1 FAD mutations.

Neurobiology of aging - 1 Jun 2016

Nikolakopoulou Angeliki M, Georgakopoulos Anastasios, Robakis Nikolaos K

Abstract excerpt

Mutants of presenilin 1 (PS1) increase neuronal cell death causing autosomal-dominant familial Alzheimer's disease (FAD). Recent literature shows that treatment of neuronal cultures with low concentrations of trypsin, a member of the serine family of proteases, protects neurons from toxic insults by binding to the proteinase-activated receptor 2 and stimulating survival kinase extracellular signal-regulated...

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Identifiers

PMID: 27143420
DOI: 10.1016/j.neurobiolaging.2016.02.028
PMCID: PMC4857890

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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