Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Attenuated presenilin-1 endoproteolysis enhances store-operated calcium currents in neuronal cells.

Journal of neurochemistry - 1 Mar 2016

Ryazantseva Maria, Skobeleva Ksenia, Glushankova Lyubov, Kaznacheyeva Elena

Abstract excerpt

Presenilins have been reported to regulate calcium homeostasis in the endoplasmic reticulum, and dysregulation of intracellular calcium has been implicated in the pathogenesis of Alzheimer's disease (AD). Reduced endoproteolysis levels of presenilin-1 (PS1) have been detected in postmortem brains of patients carrying familial Alzheimer's disease PS1 mutations. This study deals with the effect of attenuated...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer Disease
Share to Amyloid beta-Protein Precursor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Amyloid Precursor Protein Secretases

Share to Calcium

Share to Endoplasmic Reticulum

Share to Neurons

Share to Presenilin-1

Share to Presenilin-2

Source

Identifiers

PMID: 26678016
DOI: 10.1111/jnc.13495

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Attenuated presenilin-1 endoproteolysis enhances store-operated calcium currents in neuronal cells.PMID 26678016Read ↗

Familial Alzheimer's disease-associated presenilin 1 mutants promote γ-secretase cleavage of STIM1 to impair store-operated Ca2+ entry.Semantic proximity Read ↗

Presenilin mutations and calcium signaling defects in the nervous and immune systems.Semantic proximity Read ↗

Presenilin 1 Regulates Membrane Homeostatic Pathways that are Dysregulated in Alzheimer’s DiseaseSemantic proximity Read ↗

Involvement of presenilin holoprotein upregulation in calcium dyshomeostasis of Alzheimer's disease.Semantic proximity Read ↗

Presenilin-1 Delta E9 Mutant Induces STIM1-Driven Store-Operated Calcium Channel Hyperactivation in Hippocampal Neurons.Semantic proximity Read ↗

Capacitive calcium entry is directly attenuated by mutant presenilin-1, independent of the expression of the amyloid precursor protein.Semantic proximity Read ↗

Presenilins form ER Ca2+ leak channels, a function disrupted by familial Alzheimer's disease-linked mutations.Semantic proximity Read ↗

Presenilin regulates capacitative calcium entry dependently and independently of gamma-secretase activity.Semantic proximity Read ↗

Ca(2+) stores and capacitative Ca(2+) entry in human neuroblastoma (SH-SY5Y) cells expressing a familial Alzheimer's disease presenilin-1 mutation.Semantic proximity Read ↗

Susceptibility to cellular stress in PS1 mutant N2a cells is associated with mitochondrial defects and altered calcium homeostasis.Semantic proximity Read ↗

Presenilins as endoplasmic reticulum calcium leak channels and Alzheimer's disease pathogenesis.Semantic proximity Read ↗

Genetics, Functions, and Clinical Impact of Presenilin-1 (PSEN1) Gene.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.