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Article

Pharmacological knock-down of the presenilin 1 heterodimer by a novel gamma -secretase inhibitor: implications for presenilin biology.

The Journal of biological chemistry - 30 Nov 2001

Beher D, Wrigley J D, Nadin A, Evin G, Masters C L, Harrison T, Castro J L, Shearman M S

Abstract excerpt

Intramembranous cleavage of the beta-amyloid precursor protein by gamma-secretase is the final processing event generating amyloid-beta peptides, which are thought to be causative agents for Alzheimer's disease. Missense mutations in the presenilin genes co-segregate with early-onset Alzheimer's...

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Source

Identifiers

PMID: 11574530
DOI: 10.1074/jbc.M103075200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-11574530-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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