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Article

Wild-type but not FAD mutant presenilin-1 prevents neuronal degeneration by promoting phosphatidylinositol 3-kinase neuroprotective signaling.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 9 Jan 2008

Baki Lia, Neve Rachael L, Shao Zhiping, Shioi Junichi, Georgakopoulos Anastasios, Robakis Nikolaos K

Abstract excerpt

The role of presenilin-1 (PS1) in neuronal phosphatidylinositol 3-kinase (PI3K)/Akt signaling was investigated in primary neuronal cultures from wild-type (WT) and PS1 null (PS1-/-) embryonic mouse brains. Here we show that in PS1-/- cultures, the onset of neuronal maturation coincides with a decrease in the PI3K-dependent phosphorylation-activation of Akt and phosphorylation-inactivation of glycogen synthase...

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Identifiers

PMID: 18184791
DOI: 10.1523/JNEUROSCI.4067-07.2008
PMCID: PMC6670519

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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