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Article

Involvement of presenilin holoprotein upregulation in calcium dyshomeostasis of Alzheimer's disease.

Journal of cellular and molecular medicine - 1 Feb 2013

Honarnejad Kamran, Jung Christian K E, Lammich Sven, Arzberger Thomas, Kretzschmar Hans, Herms Jochen

Abstract excerpt

Mutations in presenilins (PS1 and PS2) account for the vast majority of early onset familial Alzheimer's disease cases. Beside the well investigated role of presenilins as the catalytic unit in γ-secretase complex, their involvement in regulation of intracellular calcium homeostasis has recently come into more focus of Alzheimer's disease research. Here we report that the overexpression of PS1 full-length...

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Identifiers

PMID: 23379308
DOI: 10.1111/jcmm.12008
PMCID: PMC3822592

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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