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Full-length LGR5-positive cells have chemoresistant characteristics in colorectal cancer

1 May 2016

Abstract excerpt

BACKGROUND: Leucine-rich repeat-containing G-protein-coupled receptor 5 (LGR5) is a target of Wnt signalling and considered both a cancer stem cell marker and intestinal stem cell marker. We found first some splice variants of LGR5 in human intestine and elucidated the functional feature of full-length LGR5 (LGR5FL). METHODS: Reverse transcript PCR using mRNA extracted from intestine revealed the existence of...

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PMID: 27140312
DOI: 10.1038/bjc.2016.112

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