Article

Most colitis associated carcinomas lack expression of LGR5: a preliminary study with implications for unique pathways of carcinogenesis compared to sporadic colorectal carcinoma

2020-11-20

Abstract excerpt

<title>Abstract</title> <p><bold>Background:</bold> Leucine-rich repeat-containing G-protein-coupled receptor 5 (LGR5), a component of the Wnt receptor complex, is thought to lineage label gastric and intestinal stem cells. LGR5 expression is increased in colorectal carcinoma (CRC) compared to normal tissue. Colitis associated colorectal adenocarcinoma (CAC) often shows distinct morphologic and molecular phenotyp...

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Literature Corpus work: f1edfc05-f2b0-5c62-a9bd-8e323a8dfe41
DOI: 10.21203/rs.3.rs-31590/v2

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