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Lgr5 is a potential marker of colorectal carcinoma stem cells that correlates with patient survival

15 Nov 2012

Abstract excerpt

BACKGROUND: Lgr5 (leucine-rich-repeat-containing G-protein-coupled receptor 5) has recently been identified as an intestinal stem cell marker. In order to determine whether Lgr5 is a potential marker of cancer stem cells, we investigated whether Lgr5 expression correlated with Ki-67 expression and prognosis in colorectal carcinoma. METHODS: Lgr5 and Ki-67 expression were evaluated by immunohistochemistry in 192...

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PMID: 23153436
DOI: 10.1186/1477-7819-10-244

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