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Article

Distribution of LGR5+ Cells and Associated Implications during the Early Stage of Gastric Tumorigenesis

10 Dec 2013

Abstract excerpt

Lgr5 was identified as a promising gastrointestinal tract stem cell marker in mice. Lineage tracing indicates that Lgr5(+) cells may not only be the cells responsible for the origin of tumors; they may also be the so-called cancer stem cells. In the present study, we investigated the presence of Lgr5(+) cells and their biological significance in normal human gastric mucosa and gastric tumors. RNAscope, a newly...

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PMID: 24340024
DOI: 10.1371/journal.pone.0082390

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