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Article

The interactions of age, genetics, and disease severity on tacrolimus dosing requirements after pediatric kidney and liver transplantation.

European journal of clinical pharmacology - 1 Dec 2011

de Wildt Saskia N, van Schaik Ron H N, Soldin Offie P, Soldin Steve J, Brojeni Parvaneh Yazdani, van der Heiden Ilse P, Parshuram Chris, Nulman Irena, Koren Gideon

Abstract excerpt

PURPOSE: In children, data on the combined impact of age, genotype, and disease severity on tacrolimus (TAC) disposition are scarce. The aim of this study was to evaluate the effect of these covariates on tacrolimus dose requirements in the immediate post-transplant period in pediatric kidney and liver recipients. METHODS: Data were retrospectively collected describing tacrolimus disposition, age, CYP3A5 and...

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Source

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Identifiers

PMID: 21698374
DOI: 10.1007/s00228-011-1083-7
PMCID: PMC3214266

Genes

ABCB1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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