Article
A Population Pharmacokinetic Model Does Not Predict the Optimal Starting Dose of Tacrolimus in Pediatric Renal Transplant Recipients in a Prospective Study: Lessons Learned and Model Improvement.
Clinical pharmacokinetics - 1 May 2020
Andrews Louise M, de Winter Brenda C M, Cornelissen Elisabeth A M, de Jong Huib, Hesselink Dennis A, Schreuder Michiel F, Brüggemann Roger J M, van Gelder Teun, Cransberg Karlien
Abstract excerpt
BACKGROUND AND OBJECTIVE: Bodyweight-based dosing of tacrolimus is considered standard care. Currently, at first steady state, a third of pediatric kidney transplant recipients has a tacrolimus pre-dose concentration within the target range. We investigated whether adaptation of the starting dose according to a validated dosing algorithm could increase this proportion. METHODS: This was a multi-center,...
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